N-Desmethylclozapine-d 8 (hydrochloride) is the deuterium labeled N-Desmethylclozapine hydrochloride. N-Desmethylclozapine hydrochloride is a major active metabolite of the atypical antipsychotic agent Clozapine. N-Desmethylclozapine hydrochloride is a potent, allosteric and partial M1 receptors agonist (EC50=115 nM) and is able to potentiate hippocampal N-methyl-d-aspartate (NMDA) receptor currents through M1 receptor activation. N-Desmethylclozapine hydrochloride is also a δ-opioid agonist. In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid
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N-Desmethylclozapine-d8hydrochloride
CAS number：2705402-91-9 molecular formula：C17H10D8Cl2N4
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| Chinese alias | N-去甲基氯氮平-d8盐酸盐 | ||
| English alias | - | ||
| CAS number | 2705402-91-9 | molecular formula | C17H10D8Cl2N4 |
| molecular weight | 357.31 g/mol | Exact mass | ≥99% |
| PSA | - | logp | - |
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