compound introduction
RAS/RAS-RAF-IN-1 is a potent RAS and RAS-RAF inhibitor. RAS/RAS-RAF-IN-1 has a K D of 5.0 μΜ-15 μΜ for cyclophilin A (CYPA) binding affinity. RAS/RAS-RAF-IN-1 has antitumor activity In Vitro RAS/RAS-RAF-IN-1 (compound 89; for 4 hours) has an EC 50 of 0.5 μΜ-5.0 μΜ for BRAF-GTP-KRAS-G12C disruption and has an IC 50 of 1.0 μΜ-10 μΜ for pERK inhibition in H358 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:Ras RAF
