WAY-204688 is an estrogen receptor ( ER-α ) selective, orally active inhibitor of NF-κB transcriptional activity with an IC 50 of 122 ± 30 nM for NF-κB-luciferase (NF-κB-luc) in HAECT-1 cells. In Vitro WAY-204688 is ER-dependenrt (activity seen only when hER is coexpressed with NF-κB-luciferase in human aortic endothelial cell lines (HAECT-1) cells). The interaction of WAY-204688 with ERα and ERβ is examined in vitro. WAY-204688 displaces [ 3 H]E2 from the ERα ligand binding domain protein (LBD) with IC 50 =2.43 μM and from the ERβ ligand binding domain protein (LBD) with IC 50 =1.5 μM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo WAY-204688 (5 mg/kg per day, po daily for 5 weeks) is evaluated in vivo for the ability to inhibit four proinflammatory genes (MHC, invariant chain (MHI), VCAM-1, RANTES, and TNF-α). The effect of WAY-204688 on induction of the gene products and on uterine wet weight is compared to that of 17α-ethinyl 17β-estradiol (EE at 10 μg/kg per day) in the same paradigm. Further characterization of WAY-204688 is carried out in several preclinical models of inflammatory disease. In the Lewis rat adjuvant-induced arthritis model (AIA), WAY-204688 is active at a dose of 0.3 mg/kg per day, po . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:NF-κB-luc 122 nM (IC 50 , in HAECT-1 cell) NF-κB
All
Chemical Reagents
Biomedicine
Organic raw materials
Inorganic chemical industry
intermediate
Agricultural chemicals
Auxiliaries and catalysts
Fragrances and Flavors
Dyes and Pigments
Daily chemical industry
WAY-204688
CAS number：796854-35-8 molecular formula：C34H31F3N2O2
overview
compound introduction
Specs
| Chinese alias | - | ||
| English alias | HY-19498 | JZPONCMNBSEYQW-CQTOTRCISA-N | (2R)-2-((S)-(2-Methoxyphenyl)-(1-naphthyl)methyl)-2-methyl-3-oxo-3-(4-(3-(trifluoromethyl)phenyl)-1-piperidyl)propanenitrile | Piperidine, 1-((2S,3S)-2-cyano-3-(2-methoxyphenyl)-2-methyl-3-(1-naphthalenyl)-1-oxopro | ||
| CAS number | 796854-35-8 | molecular formula | C34H31F3N2O2 |
| molecular weight | 556.62 g/mol | Exact mass | ≥99% |
| PSA | 53.300 Ų | logp | 7.800 |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
No safety information yet
Production methods and uses
No production method and use information yet
Related
upstream information
No upstream information yet
downstream information
No downstream information yet
MSDS
Found 0 shareMSDS
