LY309887 is a potent inhibitor of glycinamide ribonucleotide formyltransferase ( GARFT ), with a K i of 6.5 nM, and has antitumor activity. In Vitro LY309887 is a potent inhibitor of glycinamide ribonucleotide formyltransferase (GARFT), with a K i of 6.5 nM for human GARFT and also has high affinity at human folate receptor (FR)α and FRβ (K i , 1.78 nM and 18.2 nM, respectively). LY309887 is signigicantly cytotoxic against the human leukemia cell line CCRF-CEM with IC 50 of 9.9 nM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo LY309887 (3 mg/kg-100 mg/kg, i.p.) shows complete inhibition on the tumor growth in mice bearing C3H mammary cancer cells . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:Ki: 6.5 nM (GARFT), 1.78 nM (Folate receptor α), 18.2 nM (Folate receptor β)
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LY309887
CAS number：127228-54-0 molecular formula：C19H23N5O6S
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| Chinese alias | - | ||
| English alias | 6R-2',5'-THIENYL-5,10-DIDEAZATETRAHYDROFOLIC ACID; LY309887 | AKOS040741989 | MS-28141 | N-[(5-{2-[(6R)-2-amino-4-oxo-3,4,5,6,7,8-hexahydropyrido[2,3-d]pyrimidin-6-yl]ethyl}thiophen-2-yl)carbonyl]-L-glutamic acid | N-((5-(2-((6R)-2-Amino-3,4,5,6,7,8-hexah | ||
| CAS number | 127228-54-0 | molecular formula | C19H23N5O6S |
| molecular weight | 449.48 g/mol | Exact mass | ≥98% |
| PSA | 211.000 Ų | logp | 0.300 |
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