compound introduction
AS1269574 是一种有效的，具有口服活性的 GPR119 激动剂，在表达人 GPR119 的 HEK293 细胞中 EC50 为 2.5 μM。AS1269574 激活 TRPA1 阳离子通道，刺激胰高血糖素样肽-1 (GLP-1) 分泌。AS1269574 仅在高糖条件下特异性诱导胰腺 β 细胞分泌葡萄糖依赖性胰岛素。AS1269574 对 2 型糖尿病研究具有潜力。
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AS 1269574
CAS number：330981-72-1 molecular formula：C13H14BrN3O
overview
Specs
| Chinese alias | 2-[[2-(4-溴苯基)-6-甲基-4-嘧啶基]氨基]乙醇 | ||
| English alias | HY-107535 | 2-(2-(4-bromophenyl)-6-methylpyrimidin-4-ylamino)ethanol | DTXSID90416373 | 2-[[2-(4-Bromophenyl)-6-methyl-4-pyrinidinyl]amino]ethanol | 2-[[2-(4-bromophenyl)-6-methylpyrimidin-4-yl]amino]ethanol | AKOS005229115 | Z1095349900 | Q27074518 | 2-( | ||
| CAS number | 330981-72-1 | molecular formula | C13H14BrN3O |
| molecular weight | 308.17 g/mol | Exact mass | - |
| PSA | 58.000 Ų | logp | 2.600 |
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