compound introduction
Pozanicline dihydrochloride (ABT-089 dihydrochloride) 是一种具有口服活性的烟碱型乙酰胆碱受体 (nAChR) 激动剂，与 [3H] 胱氨酸位点结合，Ki 为 16.7 nM。Pozanicline dihydrochloride 是一种 α4β2 选择性 nAChR 激动剂，与大鼠脑 α4β2 nAChR 结合，Ki 为 17 nM，而与 α7nAChR 的结合力很弱。
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ABT 089 dihydrochloride
CAS number：161416-61-1 molecular formula：C11H18Cl2N2O
overview
Specs
| Chinese alias | 2-甲基-3-[(2S)-吡咯烷基甲氧基]吡啶二盐酸盐 | ||
| English alias | 2-Methyl-3-[(2S)-pyrrolidinylmethoxy]pyridine dihydrochloride | ||
| CAS number | 161416-61-1 | molecular formula | C11H18Cl2N2O |
| molecular weight | 265.18 g/mol | Exact mass | ≥98%(HPLC) |
| PSA | 34.200 Ų | logp | - |
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