CAS number：1197958-12-5 molecular formula：C26H34ClN6O2P
AP26113是一种有效的ALK抑制剂，无细胞试验中IC50为0.62 nM，能够克服L1196M突变介导的Crizotinib耐药性。 AP26113 is a potent ALK inhibitor with IC50 of 0.62 nM in a cell-free assay, demonstrated ability overcome Crizotinib resistance mediated by a L1196M mutation.
| Chinese alias | - | ||
| English alias | 5-Chloro-N2-[4-[4-(dimethylamino)-1-piperidinyl]-2-methoxyphenyl]-N4-[2-(dimethylphosphinyl)phenyl]-2,4-pyrimidinediamine | CCG-264698 | HMS3652H14 | Brigatinib(AP26113) | SB16487 | SCHEMBL11916416 | Q4653190 | SY001812 | MFCD23704187 | NSC776763 | NSC-77 | ||
| CAS number | 1197958-12-5 | molecular formula | C26H34ClN6O2P |
| molecular weight | 529.01 g/mol | Exact mass | ≥98% |
| PSA | 82.600 Ų | logp | 4.800 |
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