compound introduction
MK-2461是一种有效的，多靶点抑制剂，作用于c-Met(WT/mutants)，IC50为0.4-2.5 nM，对Ron，和Flt1作用效果稍弱；作用于c-Met比作用于FGFR1， FGFR2， FGFR3， PDGFRβ， KDR， Flt3， Flt4， TrkA和TrkB选择性高8到30倍。Phase 1/2。
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MK-2461
CAS number：917879-39-1 molecular formula：C24H25N5O5S
overview
Specs
| Chinese alias | - | ||
| English alias | SCHEMBL93526 | NCGC00346695-05 | CCG-264723 | FT-0631528 | NSC800795 | NSC-800795 | EX-A1566 | SY003220 | UNII-4200RD53XF | s2774 | AS-16288 | F85378 | NCGC00346695-01 | Racemic solketal | Q27086785 | JGEBLDKNWBUGRZ-HXUWFJFHSA-N | NSC764580 | NSC-764580 | | ||
| CAS number | 917879-39-1 | molecular formula | C24H25N5O5S |
| molecular weight | 495.55 g/mol | Exact mass | - |
| PSA | 124.000 Ų | logp | 1.2 |
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