CAS number：537705-08-1 molecular formula：C27H27N5O3
CP-724714是一种有效的，选择性的HER2/ErbB2抑制剂，IC50为10 nM，比作用于EGFR， InsR， IRG-1R， PDGFR， VEGFR2， Abl， Src， c-Met等选择性高640多倍。Marked selectively against EGFR and potently reduces the EGF-induced autophosphorylation. CP-724,714 is a potent, selective inhibitor of HER2/ErbB2 with IC50 of 10 nM, >640-fold selectivity against EGFR, InsR, IRG-1R, PDGFR, VEGFR2, Abl, Src, c-Met etc. Marked selectively against EGFR and potently reduces the EGF-induced autophosphorylation.
| Chinese alias | - | ||
| English alias | (E)-2-methoxy-N-(3-(4-(3-methyl-4-(6-methylpyridin-3-yloxy)phenylamino)quinazolin-6-yl)allyl)acetamide | 2-Methoxy-N-[3-[4-[[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]phenyl]amino]-6-quinazolinyl]-2-propen-1-yl]acetamide | ||
| CAS number | 537705-08-1 | molecular formula | C27H27N5O3 |
| molecular weight | 469.53 g/mol | Exact mass | ≥99% |
| PSA | - | logp | - |
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