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Upadacitinib (ABT-494)

CAS number：1310726-60-3    molecular formula：C17H19F3N6O

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overview

compound introduction

Upadacitinib (ABT-494) 是一种高效的、具有口服活性的、选择性 Janus 激酶 1 (JAK1) 抑制剂 (IC50=43 nM)。Upadacitinib 对 JAK1 的选择性约为 JAK2 (200 nM）的 74 倍。Upadacitinib 可用于多种自身免疫性疾病的研究。

Specs

Chinese alias-
English aliasABT-494 | (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide | 2,2-BIS(4,5-DIMETHYLIMIDAZOLE) | ABBV-599 COMPONENT UPADACITINIB | EX-A1628 | DB15091 | REL-(-)-(3S,4R)-3-ETHYL-4-(3H-IMIDAZO(1,2
CAS number1310726-60-3molecular formulaC17H19F3N6O
molecular weight380.37 g/molExact mass-
PSA78.300 Ųlogp2.7

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