CAS number：951151-97-6 molecular formula：C15H17ClN6O3
Information CS-2660 (JNJ-38158471) is a well tolerated, orally available, highly selectiveVEGFR-2inhibitor with IC50 of 40 nM. CS-2660 (JNJ-38158471) also inhibits closely related tyrosine kinases such asRET (c-RET)andKit (c-Kit)with IC50 of 180 nM and 500 nM，while it has no significant activity (>1 microM) against VEGFR-1 and VEGFR-3. Targets VEGFR2 (Cell-free assay); RET (Cell-free assay); Kit (Cell-free assay) 40 nM; 180 nM; 500 nM
| Chinese alias | - | ||
| English alias | Urea,N-[4-[[6-amino-5-[(methoxyimino)methyl]-4-pyrimidinyl]oxy]-2-chlorophenyl]-N'-ethyl- | ||
| CAS number | 951151-97-6 | molecular formula | C15H17ClN6O3 |
| molecular weight | 364.79 g/mol | Exact mass | 10mM in DMSO |
| PSA | 124.000 Ų | logp | 1.800 |
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