compound introduction
AVL-292是一个通过共价结合的，可以口头利用，并且具有高度选择性的BTK抑制剂，其IC50小于0.5 nM，展示了比其他被测激酶至少1400倍的选择性。Phase 1. AVL-292 is a covalent, orally active, and highly selective BTK inhibitor with IC50 of
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AVL-292
CAS number：1202757-89-8 molecular formula：C22H22FN5O3
overview
Specs
| Chinese alias | - | ||
| English alias | DRU6NG543J | HMS3674E05 | HY-18012 | n-(3-(5-fluoro-2-(4-(2-methoxyethoxy)phenylamino)pyrimidin-4-ylamino)phenyl)acrylamide | N-[3-[[5-fluoro-2-[4-(2-methoxyethoxy)anilino]pyrimidin-4-yl]amino]phenyl]prop-2-enamide | KXBDTLQSDKGAEB-UHFFFAOYSA-N | AVL 292 | ||
| CAS number | 1202757-89-8 | molecular formula | C22H22FN5O3 |
| molecular weight | 423.44 g/mol | Exact mass | - |
| PSA | 97.400 Ų | logp | 3.600 |
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