compound introduction
Information LDC1267 LDC1267 is a highly selective TAM kinase inhibitor with IC50 of Targets Mer (Cell-free assay); Tyro3 (Cell-free assay); Axl (Cell-free assay) In vitro LDC1267 moderately affects cell proliferation in 11 of 95 different cell lines with IC50 of >5μM. In NKG2D-activated NK cells, LDC1267 abolishes the inhibitory effects of Gas6 stimulation. In vivo In B16F10 melanoma-bearing mice, LDC1267 (20 mg/kg, i.p.) efficiently enhances anti-metastatic NK cell activity, and rejects tumor metastases without serious cytotoxicity. Cell Research(from reference) Cell lines：A panel of 93 cancer cell lines and two primary cells (x axis, IMR90 and human peripheral blood mononuclear cells) Concentrations：~30 μM Incubation Time：72 hours
