Osteogenic Growth Peptide (10-14) (OGP(10-14)), the C-terminal truncated pentapeptide of osteogenic growth peptide (OGP), retains the full OGP-like activity. Osteogenic Growth Peptide (10-14) is responsible for the binding to the OGP receptor and activates an intracellular Gi-protein-MAP kinase signaling pathway. Osteogenic Growth Peptide (10-14) is a potent mitogen and stimulator of osteogenesis and hematopoiesis. Osteogenic Growth Peptide (10-14) acts as a Src inhibitor. In Vitro Osteogenic Growth Peptide (10-14) (OGP(10-14)) induces proliferation and differentiation in fibroblast and osteoblast cell lines. Osteogenic Growth Peptide (10-14) induces TPO-primed M07-e cells differentiation through RhoA/TGFβ1/SFKs signalling pathway. In particular Historphin acts as a Src inhibitor, showing the same effects of PP2 . MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Osteogenic Growth Peptide (10-14) (OGP(10-14)) increases bone formation and trabecular bone density and stimulates fracture healing when administered to mice and rats . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid
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Osteogenic Growth Peptide (10-14)
CAS number：105250-85-9 molecular formula：C24H29N5O7
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| Chinese alias | 成骨生长肽（10-14） | ||
| English alias | 2-[[2-[[(2S)-2-[[2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]acetyl]amino]acetic acid | Glycine, N-(N-(N-(N-L-tyrosylglycyl)-L-phenylalanyl)glycyl)- | Historphin | AKOS040755928 | Tyr-gly-phe-gly-gly | Osteoge | ||
| CAS number | 105250-85-9 | molecular formula | C24H29N5O7 |
| molecular weight | 499.52 g/mol | Exact mass | ≥99% |
| PSA | 200.000 Ų | logp | -3.200 |
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