compound introduction
DDR1-IN-5 is a selective Discoidin Domain Receptor family, member 1 (DDR1) inhibitor with an IC 50 of 7.36 nM. DDR1-IN-5 inhibits auto-phosphorylation DDR1b (Y513) with an IC 50 of 4.1 nM. DDR1-IN-5 has anti-cancer activity In Vitro DDR1-IN-5 (compound 121; for 24 hours) inhibits collagen production in human hepatic stellate cell LX-2 (IC 50 =62 nM). DDR1-IN-5 (72 hours) has cytotoxicity in LX-2 cells (CC 50 >40 μM). MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:DDR1 7.36 nM (IC 50 )
