DDR1-IN-6 is a selective Discoidin Domain Receptor family, member 1 (DDR1) inhibitor with an IC 50 of 9.72 nM. DDR1-IN-6 inhibits auto-phosphorylation DDR1b (Y513) with an IC 50 of 9.7 nM. DDR1-IN-6 has anti-cancer activity In Vitro DDR1-IN-6 (compound 1; for 24 hours) inhibits collagen production in human hepatic stellate cell LX-2 (IC 50 =13 nM). DDR1-IN-6 (72 hours) has cytotoxicity in LX-2 cells (CC 50 =3 μM). DDR1-IN-6 (0-30 μM) has anti-proliferation effects on primary tumor cells freshly isolated from PC-07-0024 (IC 50 =5.7 μM of 3 days; IC 50 =2.65 μM of 6 days) and LU-01-0523 derived xenograft (PDX) tumor model (IC 50 >30 μM of 3 days; IC 50 >30 μM of 6 days). MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:DDR1 9.72 nM (IC 50 )
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DDR1-IN-6
CAS number：2416021-47-9 molecular formula：C23H14F3N5O
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| Chinese alias | DDR1-输入-6 | ||
| English alias | - | ||
| CAS number | 2416021-47-9 | molecular formula | C23H14F3N5O |
| molecular weight | 433.39 g/mol | Exact mass | ≥98% |
| PSA | - | logp | - |
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