Squarunkin A is a potent and selective UNC119-cargo interaction inhibitor, interrupting the UNC119A -myristoylated Src N-terminal peptide interaction ( IC 50 =10 nM). Squarunkin A interferes with the activation of Src kinase in cells In Vitro Squarunkin A (2.5 μM, 0.625 μM, 0.078 μM, and 0.01 μM) treatment leads to a concentration-dependent reduction of Src phosphorylation. Squarunkin A does not target the lipoprotein-binding sites of other lipoprotein chaperones, such as PDE6d, AIPL1, and RhoGDI, which bind S-prenylated proteins. Squarunkin A binds to UNC119 in cell lysate and interferes with Src activation. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC50: 10 nM (UNC119A-myristoylated Src N-terminal peptide interaction)
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Squarunkin A
CAS number：2101958-02-3 molecular formula：C25H32F3N5O4
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| Chinese alias | 斯夸伦金 | ||
| English alias | - | ||
| CAS number | 2101958-02-3 | molecular formula | C25H32F3N5O4 |
| molecular weight | 523.55 g/mol | Exact mass | ≥99% |
| PSA | 94.200 Ų | logp | 3.300 |
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