NAMI-A is a ruthenium-based drug characterised by the selective activity against tumour metastases, inhibits the adhesion and migration.In vitro: NAMI-A can significantly affect tumor cells with metastatic ability.The half lifetime of NAMI-A elimination from the lungs is longer than for liver, kidney, and primary tumor. NAMI-A bound to collagen is active on tumor cells as shown in vitro by an invasion test, using a modified Boyden chamber and Matrigel, and it inhibits the matrix metallo-proteinases MMP-2 and MMP-9 at micromolar concentrations.The ruthenium drug NAMI-A inhibits the adhesion and migration of colorectal cancer cells. NAMI-A decreases α5β1 integrin expression and FAK auto-phosphorylation on Tyr 397.In vivo: The reference for NAMI-A is 35 mg/kg/day. Form:Solid
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NAMI-A
CAS number：201653-76-1 molecular formula：C8H15Cl4N4ORuS
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| Chinese alias | 纳米-A | ||
| English alias | 60487Z56XW | 1H-Imidazole (OC-6-11)-tetrachloro(1H-imidazole-kappaN3)(1,1'-(sulfinyl-kappaS)bis(methane))ruthenate(1-) (1:1) | NAMI-A | 1H-imidazole;1H-imidazol-3-ium;methylsulfinylmethane;ruthenium(3+);tetrachloride | BIA65376 | 1H-IMIDAZOLE (OC-6-11)-TE | ||
| CAS number | 201653-76-1 | molecular formula | C8H15Cl4N4ORuS |
| molecular weight | 458.18 g/mol | Exact mass | ≥98% |
| PSA | - | logp | - |
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