compound introduction
JAK-IN-24 is a JAK inhibitor, with IC 50 s of 0.534 and 24 nM at the presence of 4 μM or 1mM ATP, respectively. JAK-IN-24 also inhibits PBMC IL-15 induced STAT5 phosphorylation with an IC 50 of 86.171 nM. In Vitro JAK-IN-24 (Example 129 ) inhibits JAK with IC 50 values of 0.534 and 24 nM at the presence of 4 μM or 1mM ATP respectively. JAK-IN-24 shows stability in human whole blood with t 1/2 of 267.223 min. JAK-IN-24 inhibits PBMC IL-15 induced STAT5 phosphorylation with an IC 50 of 86.171 nM. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
