GW806742X hydrochloride, an ATP mimetic and a potent MLKL (Mixed Lineage Kinase Domain-Like protein) inhibitor, binds the MLKL pseudokinase domain with a K d of 9.3 μM. GW806742X hydrochloride has activity against VEGFR2 ( IC 50 =2 nM). GW806742X hydrochl Appearance:Solid IC50& Target:MLKL|9.3 μM (Kd)|VEGFR2|2 nM (IC|50|) In Vitro:GW806742X (0.1-10000 nM) inhibits necroptotic death of wild-type mouse dermal fibroblasts (MDFs) stimulated with TSQ (1 ng/mL TNF, 500 nM compound A (Smac mimetic), 10 μM Q-VD-OPh) in a dose-dependent manner. GW806742X shows inhibition of VEGF induce Biological Activity:GW806742X hydrochloride, an ATP mimetic and a potent MLKL (Mixed Lineage Kinase Domain-Like protein) inhibitor, binds the MLKL pseudokinase domain with a K d of 9.3 μM. GW806742X hydrochloride has activity against VEGFR2 ( IC 50 =2 nM). GW806742X hydrochl
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GW806742X hydrochloride
CAS number：unknown molecular formula：C25H23ClF3N7O4S
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| Chinese alias | GW806742X 盐酸盐 | ||
| English alias | - | ||
| CAS number | unknown | molecular formula | C25H23ClF3N7O4S |
| molecular weight | 610.01 g/mol | Exact mass | ≥98% |
| PSA | - | logp | - |
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