CAS number：1392487-51-2 molecular formula：C22H22BrNO2
G-36 是细胞膜通透的 G 蛋白偶联雌激素受体(GPER/GPR30) 的非甾体拮抗剂，通过 GPER 而不是 Erα 选择性地抑制雌激素介导的 PI3K 激活。G-36 还抑制雌激素介导的钙动员 (IC50=112 nM)。 Product description G-36 is a cell permeable non-steroidal antagonist of G-protein-coupled estrogen receptor (GPER/GPR30) which selectively inhibits estrogen-mediated activation of PI3K by GPER, but not by ERα. G-36 also inhibits estrogen-mediated calcium mobilization (IC50=112 nM)
| Chinese alias | (±)-(3aR *,4S *,9bS *)-4-(6-溴-1,3-苯并二恶唑-5-基)-3a,4,5,9b-四氢-8-(1-甲基乙基) -3H-环戊[C]喹啉 | ||
| English alias | (+/-)-(3aR*,4S*,9bS*)-4-(6-Bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-8-(1-methylethyl)-3H-cyclopenta[c]quinoline | SCHEMBL24203423 | G36 | G-36 | rel-(3aR,4S,9bS)-4-(6-Bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-8-(1-methylethyl)-3H-cyclopenta | ||
| CAS number | 1392487-51-2 | molecular formula | C22H22BrNO2 |
| molecular weight | 412.33 g/mol | Exact mass | - |
| PSA | 30.500 Ų | logp | 6.000 |
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