compound introduction
LT175 是一种双重PPARα/γ配体，是口服有效PPARγ的部分激动剂 (hPPARα:EC50=0.22 μM; mPPARα:EC50=0.26 μM; hPPARγ:EC50=0.48 μM)。LT175 与PPARγ相互作用并影响辅助调节因子环 AMP 反应元件结合蛋白结合蛋白和核辅助抑制因子 1 (NCoR1) 的募集。LT175 在“二苯口袋”的疏水区域中与PPARγ相互作用。LT175 具有强大的胰岛素增敏作用和降低的脂肪生成特性。
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LT175
CAS number：862901-87-9 molecular formula：C21H18O3
overview
Specs
| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 862901-87-9 | molecular formula | C21H18O3 |
| molecular weight | 318.37 g/mol | Exact mass | ≥99% |
| PSA | 46.500 Ų | logp | 5.100 |
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