CAS number：85416-75-7 molecular formula：C16H21NO3
(R)-(-)-Rolipram是cAMP-特异的PDE4抑制剂，IC50为220nM。在抑制PDE4膜结合实验中其抑制性高于(+)-rolipram 2.5倍。 (R)-(-)-Rolipram is a potent and cAMP-specific PDE4 inhibitor with IC50 of 0.22 uM; 2.5-fold more potent than (+)-rolipram (IC50= 2.58 uM) in inhibiting membrane-bound PDE 4.
| Chinese alias | (R)-(-)-咯利普兰 | (R)-(-)-4-[3-(环戊氧基)-4-甲氧基苯基]吡咯烷 -2-酮 | ||
| English alias | DTXSID101318033 | J-010435 | NCGC00015898-01 | (4R)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE | Tocris-1350 | CHEBI:40133 | Lopac-R-6520 | 1ro6 | 2-Pyrrolidinone, 4-(3-(cyclopentyloxy)-4-methoxyphenyl)-, (R)- | R-Rolipram | (R)-4-(3-Cyclopent | ||
| CAS number | 85416-75-7 | molecular formula | C16H21NO3 |
| molecular weight | 275.35 g/mol | Exact mass | ≥97% |
| PSA | 47.600 Ų | logp | 2.200 |
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