Cadherins (Calcium dependent adhesion molecules) are a class of transmembrane proteins. Cadherin-5, also known as VE-cadherin, CDH5 and CD144, an endothelial specific cell-cell adhesion molecule, plays a pivotal role in the formation, maturation and remodeling of the vascular wall. VE-Cadherin is widely considered to be specific for vascular endothelia in which it is either the sole or the predominant cadherin, often co-existing with N-cadherin. This specificity of VE-cadherin for vascular endothelial cells is important not only in blood and lymph vessel biology and medicine, but also for cell-type-based diagnoses, notably those of metastatic tumors. As a classical cadherin, VE-Cadherin links endothelial cells together by homophilic interactions mediated by its extracellular part and associates intracellularly with the actin cytoskeleton via catenins. Mechanisms that regulate VE-cadherin-mediated adhesion are important for the control of vascular permeability and leukocyte extravasation. In addition to its adhesive functions, VE-Cadherin regulates various cellular processes such as cell proliferation and apoptosis and modulates vascular endothelial growth factor receptor functions. Consequently, VE-cadherin is essential during embryonic angiogenesis.
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Recombinant Human VE-Cadherin Protein
CAS number：unknown molecular formula：
overview
compound introduction
Specs
| Chinese alias | 重组人VE-Cadherin蛋白 | 重组人VE-钙粘蛋白 | ||
| English alias | 7B4 | 7B4 antigen | cadherin 5, type 2 (vascular endothelium) | cadherin 5, type 2, VE-cadherin (vascular epithelium) | Cadherin-5 | CD144 antigen | CD144 | CDH5 | endothelial-specific cadherin | FLJ17376 | Vascular endothelial cadherin | VECadherin | VE- | ||
| CAS number | unknown | molecular formula | |
| molecular weight | - | Exact mass | 无动物源 |
| PSA | - | logp | - |
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