Purity:≥95%, by SDS-PAGE visualized with Coomassie® Blue Staining. Description： Programmed Death-1 receptor (PD-1), also known as CD279, is a type I transmembrane protein belonging to the CD28 family of immune regulatory receptors. Other members of this family include CD28, CTLA-4, ICOS, and BTLA. Mature human PD-1 consists of a 148 amino acid (aa) extracellular region (ECD) with one immunoglobulin-like V-type domain, a 24 aa transmembrane domain, and a 95 aa cytoplasmic region. The human PD-1 ECD shares 65% aa sequence identity with the mouse PD-1 ECD. The cytoplasmic tail contains two tyrosine residues that form the immunoreceptor tyrosine-based inhibitory motif (ITIM) and immunoreceptor tyrosine-based switch motif (ITSM) that are important for mediating PD-1 signaling. PD-1 acts as a monomeric receptor and interacts in a 1:1 stoichiometric ratio with its ligands PD-L1 (B7-H1) and PD-L2 (B7-DC). PD‑1 is expressed on activated T cells, B cells, monocytes, and dendritic cells while PD-L1 expression is constitutive on the same cells and also on nonhematopoietic cells such as lung endothelial cells and hepatocytes. Ligation of PD-L1 with PD-1 induces co-inhibitory signals on T cells promoting their apoptosis, anergy, and functional exhaustion. Thus, the PD-1: PD-L1 interaction is a key regulator of the threshold of immune response and peripheral immune tolerance. Finally, blockade of the PD-1: PD-L1 interaction by either antibodies or genetic manipulation accelerates tumor eradication and shows potential for improving cancer immunotherapy.
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Recombinant Human PD-1 Protein
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Specs
| Chinese alias | 重组人PD-1蛋白 | 重组人PD-1蛋白 | ||
| English alias | PDCD1_HUMAN | Programmed cell death 1 | Programmed cell death 1 protein | Programmed cell death protein 1 | Protein PD 1 | Protein PD-1 | SLEB2 | Systemic lupus erythematosus susceptibility 2 | CD279 | CD279 antigen | hPD 1 | hPD l | hPD-1 | hSLE1 | PD 1 | ||
| CAS number | unknown | molecular formula | |
| molecular weight | - | Exact mass | 无动物源 |
| PSA | - | logp | - |
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