CAS number：1025065-69-3 molecular formula：C20H22F3N5O
SGI-1776 free base是一种新型的，ATP竞争性的Pim1抑制剂，IC50为7 nM，比作用于Pim2和Pim3选择性分别高50和10倍，作用于Flt3和haspin也有效。A potent apoptotic that targets Pim and FLT3 in AML and CLL cells. SGI-1776 is a novel ATP competitive inhibitor of Pim1 with IC50 of 7 nM, 50- and 10-fold selective versus Pim2 and Pim3, also potent to Flt3 and haspin A potent apoptotic that targets Pim and FLT3 in AML and CLL cells.
| Chinese alias | - | ||
| English alias | N-[(1-methylpiperidin-4-yl)methyl]-3-[3-(trifluoromethoxy)phenyl]imidazo[2,1-f]pyridazin-6-amine | Imidazo[1,2-b]pyridazin-6-amine, N-[(1-methyl-4-piperidinyl)methyl]-3-[3-(trifluoromethoxy)phenyl]- | NSC800883 | NSC-800883 | SB19298 | AC-28432 | N-((1-Me | ||
| CAS number | 1025065-69-3 | molecular formula | C20H22F3N5O |
| molecular weight | 405.42 g/mol | Exact mass | - |
| PSA | 54.700 Ų | logp | 4.300 |
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