compound introduction
Autophinib 是一种有效的，选择性细胞自噬抑制剂，对于饥饿和 Rapamycin 诱导的自噬，IC50 值分别为 90 nM 和 40 nM。Autophinib 还是一种 ATP 竞争性的 VPS34 抑制剂，其 IC50 值为 19 nM。Autophinib 通过靶向 VPS34 来抑制饥饿或 Rapamycin 诱导的细胞自噬。
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Autophinib
CAS number：1644443-47-9 molecular formula：C14H11ClN6O3
overview
Specs
| Chinese alias | 6-氯-N-(5-甲基-1H-吡唑-3-基)-2-(4-硝基苯氧基)-嘧啶胺 | ||
| English alias | 6-chloro-N-(5-methyl-1H-pyrazol-3-yl)-2-(4-nitrophenoxy)pyrimidin-4-amine | 6-Chloro-N-(5-methyl-1H-pyrazol-3-yl)-2-(4-nitrophenoxy)-4-pyrimidinamine | ||
| CAS number | 1644443-47-9 | molecular formula | C14H11ClN6O3 |
| molecular weight | 346.73 g/mol | Exact mass | ≥98%(HPLC) |
| PSA | 122.000 Ų | logp | 3.800 |
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