compound introduction
MMAF (Monomethylauristatin F) 是一种合成抗肿瘤药，是 tubulin 聚合的有效抑制剂。MMAF (Monomethylauristatin F) 可被用作抗体偶联药物(ADCs, 例如 vorsetuzumab mafodotin、ABT-414和SGN-CD19A)中的细胞毒性成分。
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MMAF
CAS number：745017-94-1 molecular formula：C39H65N5O8
overview
Specs
| Chinese alias | (S)-2-((2R,3R)-3-((S)-1-((3R,4S,5S)-4-((S)-N,3-二甲基-2-((S)-3-甲基-2-(甲胺基)丁酰胺基)丁酰胺基)-3-甲氧基-5-甲基庚酰)吡咯烷-2-基)-3-甲氧基-2-甲基丙酰胺基)-3-苯基丙酸 | 一甲基澳瑞他汀 F | ||
| English alias | MMAF | 745017-94-1 | Monomethyl Auristatin F | (2S)-2-[[(2R,3R)-3-methoxy-3-[(2S)-1-[(3R,4S,5S)-3-methoxy-5-methyl-4-[methyl-[(2S)-3-methyl-2-[[(2S)-3-methyl-2-(methylamino)butanoyl]amino]butanoyl]amino]heptanoyl]pyrrolidin-2-yl]-2-methylpropanoyl]amino]- | ||
| CAS number | 745017-94-1 | molecular formula | C39H65N5O8 |
| molecular weight | 731.96 g/mol | Exact mass | - |
| PSA | 167.000 Ų | logp | 2.100 |
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