DBCO-PEG₄-maleimide 是马来酰亚胺官能化的环辛炔衍生物， 是一种可降解(cleavable)的ADC linker，用于抗体偶联药物(ADCs)的合成。也用于将环辛炔部分掺入含硫醇的化合物或生物分子中。环辛炔可用于应变促进的无铜叠氮化物-炔烃环加成反应。该二苯并环辛炔将与叠氮化物官能化的化合物或生物分子反应，而无需Cu（I）催化剂即可产生稳定的三唑键。当标记生物分子时，PEG亲脂性间隔基有助于减少聚集和沉淀问题。 DBCO-PEG|4|-maleimide is a maleimide functionalized cyclooctyne derivative for incorporation of the cyclooctyne moiety into thiol containing compounds or biomolecules. Cyclooctynes are useful in strain-promoted copper-free azide-alkyne cycloaddition reactions. This dibenzocyclooctyne will react with azide functionalized compounds or biomolecules without the need for a Cu(I) catalyst to result in a stable triazole linkage. The PEG lipophilic spacer helps to reduce aggregation and precipitation problems when labeling biomolecules.
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DBCO-PEG₄-maleimide
CAS number：1480516-75-3 molecular formula：C36H42N4O9
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| Chinese alias | 氮杂二苯并环辛炔-PEG4-马来酰亚胺 | 二苄环辛基-PEG4-马来酰亚胺 | ||
| English alias | 1H-Pyrrole-1-propanamide, N-[19-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-15,19-dioxo-3,6,9,12-tetraoxa-16-azanonadec-1-yl]-2,5-dihydro-2,5-dioxo- | GS-9438 | BCP30925 | AKOS040741607 | Dibenzocyclooctyne-PEG4-maleimide, for Copper-free Click Chemistry | ||
| CAS number | 1480516-75-3 | molecular formula | C36H42N4O9 |
| molecular weight | 674.74 g/mol | Exact mass | ≥95% |
| PSA | 153.000 Ų | logp | 0.000 |
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