NAMPT inhibitor-linker 1 is a agent-linker conjugates for ADC , composed of an NAMPT inhibitor as a payload, and a linker. ADC-3 consists of an NAMPT inhibitor-linker 1 and an anti-c-Kit monoclonal antibody, exihibits potent activity against c-Kit expressing cell lines such as GIST-T1 and NCI-H526 cells, with IC 50 s of In Vitro ADC-3 exihibits potent activity against c-Kit expressing cell lines such as GIST-T1 and NCI-H526, with IC 50 s of In Vivo ADC-3 (20 mg/kg, i.v. for 28 days) is tolerated, and causes tumor stasis in mice bearing GIST-T1 cells . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Female scid-beige (SCID bg) mice Dosage: 20 mg/kg Administration: A single intravenous injection (i.v.) for 28 days Result: Significantly inhibited the growth of tumor in mice. Form:Solid IC50& Target:Traditional Cytotoxic Agents
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NAMPT inhibitor-linker 1
CAS number：2241019-57-6 molecular formula：C36H37FN6O6
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| Chinese alias | NAMPT 抑制剂-连接子 1 | ||
| English alias | - | ||
| CAS number | 2241019-57-6 | molecular formula | C36H37FN6O6 |
| molecular weight | 668.71 g/mol | Exact mass | - |
| PSA | - | logp | - |
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