Seco-DUBA is a duocarmycin (DUBA) prodrug containing two hydroxyl groups, which can each be used for coupling to an antibody via a linker. Seco-DUBA can be used in the synthesis of antibody-drug conjugates (ADCs). In Vitro Seco-DUBA (SK-BR-3 cells; 0.0001 pM~0.01 nM; 144 hours) dose-dependent reduces cell viability and shows equally potent and efficacious as DUBA. Seco-DUBA causes SK-BR-3 (IC 50 =0.09), SK-OV-3 (IC 50 =0.43), and SW620 (IC 50 =0.09) cells to exhibit highly sensitive. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Cytotoxicity AssayCell Line: SK-BR-3 cells Concentration: 0.0001 pM~0.01 nM Incubation Time: 144 hours Result: Dose-dependent reduced cell viability. In Vivo Seco-DUBA (89 μg/kg; i.v.) is likely converted to DUBA almost instantaneously . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Wistar rats Dosage: 89 μg/kg (Pharmacokinetic Analysis) Administration: I.v. Result: Likely converted to DUBA almost instantaneously. Form:Solid
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Seco-DUBA Hydrochloride
CAS number：1795733-93-5 molecular formula：C29H23ClN4O4.xHCl
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| Chinese alias | 盐酸塞科杜巴 | ||
| English alias | - | ||
| CAS number | 1795733-93-5 | molecular formula | C29H23ClN4O4.xHCl |
| molecular weight | 526.97（free） g/mol | Exact mass | ≥95% |
| PSA | - | logp | - |
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