Taltobulin hydrochloride (HTI-286 hydrochloride), a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo. Taltobulin hydrochloride inhibits the polyme IC50& Target:Traditional Cytotoxic Agents In Vitro:Taltobulin (HTI-286; 0.2-7.3 nM; 3 days) inhibits the growth of 18 tumor cell lines (leukemia, ovarian, NSCLC, breast, colon, and melanoma cell lines) with an average IC 50 of 2.5±2.1 nM and a median value of 1.7 nM. MCE has not independently confirm In Vivo:Taltobulin (HTI-286; 1.6mg/kg i.v.) inhibits the growth of human tumor xenografts (e.g., HCT-15, DLD-1, MX-1W, and KB-8-5) in athymic nu/nu female mice. Taltobulin (HTI-286; 3mg/kg; p.o. gavage) inhibits growth by 97.3 % and 82% in athymic nu/nu fe Biological Activity:Taltobulin hydrochloride (HTI-286 hydrochloride), a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo. Taltobulin hydrochloride inhibits the polyme
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Taltobulin hydrochloride
CAS number：unknown molecular formula：C27H44ClN3O4
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| Chinese alias | 盐酸他妥布林 | ||
| English alias | - | ||
| CAS number | unknown | molecular formula | C27H44ClN3O4 |
| molecular weight | 510.11 g/mol | Exact mass | 10mM in DMSO |
| PSA | - | logp | - |
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