Sacubitril calcium

CAS number：1369773-39-6 molecular formula：C24H28NO5 · 0.5Ca

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Sacubitril (AHU-377) hemicalcium salt 是有效的NEP抑制剂，IC50值为5 nM。Sacubitril hemicalcium salt 是研究心力衰竭药物 LCZ696 的一个组分。

Chinese alias	(αR,γS)-γ-[(3-羧基-1-氧丙基)氨基]-α-甲基-[1,1'-联苯] -4-戊酸半钙盐 \| AHU377 钙盐 \| AHU-377 钙盐 \| 4-{[(2S,4R)-1-(4-联苯基)-5-乙氧基-4-甲基-5-氧代-2-戊烷基]氨基}-4-氧代丁酸 \| (2R,4S)-5-(联苯-4-基)-4-[(3-羧基丙酰基)氨基]-2-甲基戊酸乙酯 \| (2R,4S)-4-[(3-羧基-1-丙酰基)氨基]-4-[(对-联苯基)甲基]-2-甲基丁酸乙酯 \| 4-[[(2S,4R)-5-乙氧基-4-甲基
English alias	1369773-39-6 \| AHU-377 hemicalcium salt \| Sacubitril calcium \| Sacubitril hemicalcium salt \| AHU-377 calcium salt \| 8F45HCQ47Q \| UNII-8F45HCQ47Q \| 4-(((2S,4R)-5-Ethoxy-4-methyl-5-oxo-1-(4-phenylphenyl)pentan-2-yl)amino)-4-oxobutanoic acid calcium salt, \|
CAS number	1369773-39-6	molecular formula	C24H28NO5 · 0.5Ca
molecular weight	430.52 g/mol	Exact mass	10mM in DMSO
PSA	191.000 Å²	logp	-

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