compound introduction
GN44028 是一种缺氧诱导因子(HIF)-1的有效抑制剂，其IC50 值为 14 nM。GN44028 能抑制低氧诱导的HIF-1α 的转录活性，但不抑制HIF-1α mRNA 的表达，HIF-1α 蛋白的累积或HIF-1α/HIF-1β 的异缘二聚化。
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GN 44028
CAS number：1421448-26-1 molecular formula：C18N15N3O2
overview
Specs
| Chinese alias | N-(2,3-二氢-1,4-苯并二恶英-6-基)-1,4-二氢茚并[1,2-c]吡唑-3-胺 | ||
| English alias | N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine | GN44028 | ||
| CAS number | 1421448-26-1 | molecular formula | C18N15N3O2 |
| molecular weight | 305.33 g/mol | Exact mass | ≥98%(HPLC) |
| PSA | 59.200 Ų | logp | 3.500 |
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