compound introduction
DDMS是一种基于机理的不可逆抑制剂，对主要在哺乳动物肾脏中合成20-HETE的CYP4A11（CYP450 4A2）酶具有约10倍的选择性。在全麻大鼠（10 mg / kg）中使用DDMS可以大大消除一氧化氮供体（如NONOates）引起的低血压和血管舒张。CYP4A11（细胞色素P450 4A）亚型由花生四烯酸生物合成20-HETE是血管稳态的重要组成部分，尤其是在肾脏循环中。 DDMS is a mechanism-based, irreversible inhibitor that has about 10-fold selectivity for the CYP4A11 (CYP450 4A2) enzyme which predominantly synthesizes 20-HETE in the mammalian kidney. DDMS administration in whole anesthetized rats (10 mg/kg) largely ablates the hypotension and vasodilation induced by nitric oxide donors such as NONOates. Biosynthesis of 20-HETE from arachidonic acid by the CYP4A11 (cytochrome P450 4A) isoforms is an important component of vascular homeostasis, especially in renal circulation.
