compound introduction
16,16-二甲基前列腺素A2是PGA2的抗代谢类似物，具有相对较长的半衰期。已显示该化合物以4 µg / ml的浓度抑制培养的非洲绿猴肾细胞中的仙台病毒增殖> 90％。此外，每天向感染甲型流感病毒的小鼠中输注10 µg 16,16-二甲基PGA2甲酯可使存活率提高40％。接种红白血病细胞的小鼠的类似治疗可延迟肿瘤生长并延长生存时间。 16,16-dimethyl Prostaglandin A2 is a metabolism resistant analog of PGA2 with a relatively prolonged half-life. This compound has been shown to inhibit the proliferation of Sendai virus in cultured African green monkey kidney cells by >90% at a concentration of 4 μg/ml. Additionally, daily infusion of 10 μg of 16,16-dimethyl PGA2 methyl ester into mice infected with influenza A virus increased survival by 40%. Similar treatment of mice inoculated with erythroleukemia cells delayed tumor growth and increased survival time.
