Information Subasumstat (TAK-981) Subasumstat (TAK-981) is a novel, selective inhibitor of the SUMOylation enzymatic cascade with potential immune-activating and antineoplastic activities. Targets SUMOylation enzymatic cascade In vitro In both mouse bone-marrow and human peripheral blood mononuclear cell derived dendritic cells (DCs), TAK-981 treatment ex vivo induced markers of activation and maturation including CD40, CD80 and CD86, as well as increased secretion of inflammatory cytokines like IP-10, MCP1, MIP-1α, MIP1β, IFNα and IFNβ. In vivo a single sub-cutaneous injection of TAK-981 in naïve Balb/c mice at the brachial lymph nodes induced activation of DCs, measured as significant increases in CD40 and CD86 expression. TAK-981 demonstrates antitumor activity, including complete regression (CR) of some tumors, in immune-competent BALB/c mice bearing syngeneic A20 lymphoma tumors. Cell Research(from reference) Cell lines：mouse bone-marrow and human peripheral blood mononuclear cell derived dendritic cells (DCs)
All
Chemical Reagents
Biomedicine
Organic raw materials
Inorganic chemical industry
intermediate
Agricultural chemicals
Auxiliaries and catalysts
Fragrances and Flavors
Dyes and Pigments
Daily chemical industry
Subasumstat (TAK-981)
CAS number：1858276-04-6 molecular formula：C25H28ClN5O5S2
overview
compound introduction
Specs
| Chinese alias | 苏巴坦 (TAK-981) | ||
| English alias | [(1R,2S,4R)-4-{[5-({4-[(1R)-7-chloro-1,2,3,4-tetrahydroisoquinolin-1-yl]-5-methyl-2- thienyl}carbonyl)pyrimidin-4-yl]amino}-2-hydroxycyclopentyl]methyl sulfamate | LXRZVMYMQHNYJB-UNXOBOICSA-N | Sumoylation inhibitor TAK-981 | SUBASUMSTAT [WHO-DD] | 185827 | ||
| CAS number | 1858276-04-6 | molecular formula | C25H28ClN5O5S2 |
| molecular weight | 578.10 g/mol | Exact mass | - |
| PSA | 193.000 Ų | logp | 3.500 |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
No safety information yet
Production methods and uses
No production method and use information yet
Related
upstream information
No upstream information yet
downstream information
No downstream information yet
MSDS
Found 0 shareMSDS
