CAS number：2174-59-6 molecular formula：C20H20O8
Demethylnobiletin (5-Demethylnobiletin)是一种在柑橘类水果中发现的独特的类黄酮，具有潜在的化学预防人类癌症的作用。5-Demethylnobiletinin 是 5-LOX 的直接抑制剂，IC50值为0.1 μM，且不影响COX-2的表达。5-Demethylnobiletinin 具有抗炎活性，可抑制大鼠中性粒细胞中 leukotriene B 4(LTB4) 的形成和人中性粒细胞中elastase弹性蛋白酶 (elastase) 的释放，IC50为0.35 μM。
| Chinese alias | 5-O-去甲肾上腺素 | ||
| English alias | FT-0698018 | NSC618927 | NSC-618927 | AKOS016010675 | 5-Demethylnobiletin | SPECTRUM1505030 | SCHEMBL1764120 | 2-(3,4-Dimethoxyphenyl)-5-hydroxy-6,7,8-trimethoxy-4H-1-benzopyran-4-one | Flavone, 5-hydroxy-3',4',6,7,8-pentamethoxy- | NCGC00094903-01 | BRD- | ||
| CAS number | 2174-59-6 | molecular formula | C20H20O8 |
| molecular weight | 388.38 g/mol | Exact mass | ≥98% |
| PSA | 92.700 Ų | logp | 3.200 |
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