Firsocostat (GS-0976, NDI-010976, ND-630)是acetyl CoA carboxylase (ACC)的一种可逆抑制剂，对hACC1和hACC2的IC50分别为2.1 nM，6.1 nM。 Information Firsocostat (GS-0976) Firsocostat (GS-0976, NDI-010976, ND-630) is a reversible inhibitor of acetyl CoA carboxylase (ACC) with IC50s of 2.1 nM,6.1 nM for hACC1 and hACC2,respectively. Targets hACC1 (Cell-free assay); hACC2 (Cell-free assay) 2.1 nM; 6.1 nM In vitro When ND-630 and [ 14 C]acetate were administered to Hep-G2 cells for 4 h, ND-630 inhibited FASyn with EC50 values of 66 nM in cells cultured in medium containing. When ND-630 and[ 14 C]palmitate were administered to C2C12 cells for 6 h, ND-630 increased both the release of [ 14 C]O 2 and the production of[ 14 C]acid-soluble material. In vivo When administered chronically to rats with diet-induced obesity, ND-630 reduces hepatic steatosis, improves insulin sensitivity, reduces weight gain without affecting food intake, and favorably affects dyslipidemia.
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Firsocostat (GS-0976)
CAS number：1434635-54-7 molecular formula：C28H31N3O8S
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| Chinese alias | - | ||
| English alias | FIRSOCOSTAT [WHO-DD] | ND-630; NDI-010976; Firsocostat | FIRSOCOSTAT [INN] | BS-15388 | THIENO(2,3-D)PYRIMIDINE-3(2H)-ACETIC ACID, 1,4-DIHYDRO-1-((2R)-2-(2-METHOXYPHENYL)-2-((TETRAHYDRO-2H-PYRAN-4-YL)OXY)ETHYL)-.ALPHA.,.ALPHA.,5-TRIMETHYL-6-(2-OXAZOLYL)-2 | ||
| CAS number | 1434635-54-7 | molecular formula | C28H31N3O8S |
| molecular weight | 569.63 g/mol | Exact mass | - |
| PSA | 160.000 Ų | logp | 2.946 |
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