Information MCU-i4 MCU-i4 is a negative modulator of the mitochondrial calcium uniporter (MCU) complex that directly binds a specific cleft in MICU1 and decreases mitochondrial Ca2+ influx. Targets MCU1 In vitro MCU-i4 decreases mitochondrial Ca2+ influx. Docking simulations reveal that MCU-i4 directly binds a specific cleft in MICU1, a key element of the MCU complex that controls channel gating. Accordingly, in MICU1-silenced or deleted cells, the inhibitory effect of MCU-i4 is lost. Moreover, MCU-i4 fails to inhibit mitochondrial Ca2+ uptake in cells expressing a MICU1 mutated in the critical amino acids that forge the predicted binding cleft. Cell Research(from reference) Cell lines：C2C12 myoblasts Concentrations：10 μM Incubation Time：24 h
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MCU-i4
CAS number：371924-24-2 molecular formula：C23H27N3O2
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| Chinese alias | - | ||
| English alias | 3-Quinolinecarboxylic acid,4-[[4-(diethylamino)phenyl]amino]-6-methyl-,ethyl ester | ||
| CAS number | 371924-24-2 | molecular formula | C23H27N3O2 |
| molecular weight | 377.48 g/mol | Exact mass | ≥99% |
| PSA | 54.500 Ų | logp | 5.700 |
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