PF-06747711 is a potent, selective, and orally active retinoic acid receptor-related orphan C2 ( RORC2 , also known as RORγt ) inverse agonist, with an IC 50 of 4.1 nM. Anti-skin inflammatory activity In Vitro PF-06747711 (Compound 66) reduces IL-17 production by human Th17 cells with an IC 50 of 9.5 nM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo PF-06747711 (10, 30, and 100 mg/kg, p.o., daily over 5 days) inhibits ear swelling in a dose-dependent manner in mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: 8−10 week old female Balb/c mice Dosage: 10, 30, and 100 mg/kg Administration: P.O. daily over 5 days Result: Inhibited ear swelling, and caused a maximum inhibition of 46% at 100 mg/kg. Form:Solid IC50& Target:IC50: 4.1 nM (RORC2)
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PF-06747711
CAS number：1892576-58-7 molecular formula：C26H26F3N5O2
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 1892576-58-7 | molecular formula | C26H26F3N5O2 |
| molecular weight | 497.51 g/mol | Exact mass | ≥99% |
| PSA | 91.000 Ų | logp | 3.800 |
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