MitoBloCK-10 (MB-10) is the first small molecule modulator to attenuate protein-associated motor (PAM) complex activity. MitoBloCK-10 (MB-10) inhibits Tim44 (C-terminal domain) binding to the precursor and to Hsp70. In Vitro MB-10 (100 μM) is a potential attenuator of protein import into mitochondria. ? MB-10 inhibits the import of substrates that use the TIM23 import pathway. ? MB-10 (0-100 μM) inhibits protein import into mammalian mitochondria. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: A plasmid expressing Su9-Ura3-myc was integrated at the LEU2 locus in WT and tim23-2 strains. Concentration: 100 μM. Incubation Time: 30 min. Result: WT strain expressing Su9-Ura3 failed to grow, whereas the tim23-2 mutant expressing Su9-Ura3 grew much faster. The strains grew at a similar rate when the medium was supplemented with uracil. Cell Viability AssayCell Line: HeLa cells. Concentration: 0-100 μM. Incubation Time: 24 h. Result: Inhibited HeLa cells vibility, with an IC 50 of 17.2 μM. Form:Solid
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MitoBloCK-10
CAS number：394694-98-5 molecular formula：C12H8FN3O3S
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 394694-98-5 | molecular formula | C12H8FN3O3S |
| molecular weight | 293.28 g/mol | Exact mass | ≥98% |
| PSA | 116.000 Ų | logp | 3.100 |
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