GSK2945 hydrochloride is a class of tertiary amine, and is a highly specific Rev-erbα / REV-ERBα (mouse/human reverse erythroblastosis virus α) antagonist with EC 50 s of 21.5 μM and 20.8 μM, respectively. GSK2945 hydrochloride enhances cholesterol 7α-hyd Appearance:Solid In Vitro:GSK2945 dose-dependently enhances the transcriptional activity of Rev-erbα and a Bmal1 (a target gene of REV-ERBs) luciferase reporter ( EC 50 of 2.05 μM). GSK2945 (20 μM; 12 hours and 24 hours; mouse and human primary hepatocytes) treatment incre In Vivo:GSK2945 (0-10mg/kg; intraperitoneal injection; twice every day; for 7 days; male C57BL/6 mice) treatment increases hepatic mouse cholesterol 7α-hydroxylase (Cyp7a1) level and lowers plasma cholesterol in wild-type mice. MCE has not independently con Biological Activity:GSK2945 hydrochloride is a class of tertiary amine, and is a highly specific Rev-erbα / REV-ERBα (mouse/human reverse erythroblastosis virus α) antagonist with EC 50 s of 21.5 μM and 20.8 μM, respectively. GSK2945 hydrochloride enhances cholesterol 7α-hyd
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GSK2945 hydrochloride
CAS number：unknown molecular formula：C20H19Cl3N2O2S
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| Chinese alias | GSK2945 盐酸盐 | ||
| English alias | - | ||
| CAS number | unknown | molecular formula | C20H19Cl3N2O2S |
| molecular weight | 457.8 g/mol | Exact mass | ≥99% |
| PSA | - | logp | - |
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