Demethylcantharidate disodium, an endogenous metabolite , induces apoptosis in hepatocellular carcinoma cells via ER stress. Demethylcantharidate disodium shows excellent anticancer activity against multiple types of cancer. In Vitro Demethylcantharidate (0-100 μM; 0, 12, 24, 48 or 72 hours) disodium inhibits HCC cell proliferation. Demethylcantharidate (0, 9, 18 or 36 µM; 24 hours) disodium dose dependently increases the levels of cleaved caspase-3, cleaved caspase-9, and Bax/Bcl-2. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: HCC cell lines (SMMC-7721 and Bel-7402) Concentration: 0-100 μM Incubation Time: 0, 12, 24, 48 or 72 hours Result: Showed anti-proliferative activity in the two HCC cell lines. Cell Viability AssayCell Line: HCC cells Concentration: 0, 9, 18 or 36 µM Incubation Time: 24 hours Result: Induced apoptosis in HCC cells via the intrinsic pathway. In Vivo Demethylcantharidate disodium significantly decreases hepatocellular carcinoma tumorigenesis of SMMC-7721 cells in vivo . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid
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Demethylcantharidate disodium
CAS number：129-67-9 molecular formula：C8H8Na2O5
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| Chinese alias | 去甲基斑蝥酸二钠 | ||
| English alias | - | ||
| CAS number | 129-67-9 | molecular formula | C8H8Na2O5 |
| molecular weight | 230.13 g/mol | Exact mass | ≥98% |
| PSA | - | logp | - |
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