PF-03654746 是一种有效的选择性组胺 H3 receptor 拮抗剂,具有脑渗透性。PF-03654746 可减少过敏原引起的鼻炎反应。PF-03654746 Tosylate (PF-03654746)可以用于人类认知障碍,改善阿尔茨海默症 (AD) 的相关研究。 PF-03654746 is a potent and selective histamine H3 receptor antagonist with high brain penetration. PF-03654746 reduces allergen-induced nasal symptoms, might be a novel therapeutic strategy to further explore allergic rhinitis. PF-03654746 improves cognitive efficacy and disease-modifying effects in Alzheimer's disease (AD)
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PF-03654746
CAS number:935840-31-6 molecular formula:C18H24F2N2O
overview
compound introduction
Specs
| Chinese alias | compound 6 | PF 03654746 | PF03654746 | ||
| English alias | N-ethyl-3-fluoro-3-[3-fluoro-4-(pyrrolidin-1-ylmethyl)phenyl]cyclobutane-1-carboxamide | G3QE979K1X | ||
| CAS number | 935840-31-6 | molecular formula | C18H24F2N2O |
| molecular weight | 322.39 g/mol | Exact mass | - |
| PSA | 32.299 Ų | logp | 2.5 |
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