compound introduction
CaV1.3 antagonist-1 is a potent and highly selective Ca V 1.3 L-type calcium channel (LTCC) antagonist with an IC 50 of 1.7 μM. CaV1.3 antagonist-1 inhibits Ca V 1.3 LTCC >600-fold more potently than Ca V 1.2 LTCC. CaV1.3 antagonist-1, a cyclopentyl derivative, has the potential for Parkinson's disease research In Vitro CaV1.3 antagonist-1 (Compound 8; 5 μM) exhibits 31.2% and 4.4% inhibition for Ca V 1.3 and Ca V 1.2 channel current in HEK293 cells, respectively. This correlates with the results of the FLIPR assay. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:Ca V 1.3 1.7 μM (IC 50 )
