Ispronicline (TC-1734), an orally active, brain-selective α4β2 nicotine acetylcholine receptor ( nAChR ) partial agonist, has shown memory-enhancing properties in rodents and a good tolerability profile. Ispronicline binds to the α4β2 nAChR with high affinity ( K i =11 nM) and is highly selective to other nAChRs such as α7 nAChR and α3β4 nAChR. In Vivo Ispronicline (10-20 mg/kg; s.c.) induces c-Fos expression in selective regions of the rat forebrain . Ispronicline pharmacokinetics (half-life of 2 h in rats) contrasts with the long-lasting improvement of working memory (18 h to 2 d). MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male Wistar rats weighting 180-200 g Dosage: 10 and 30 mg/kg Administration: s.c. Result: Induced c-Fos in medial paraventricular nucleus of hypothalamus. Treatment with 30 mg/kg ispronicline, but not 10 mg/kg, increased the number of c-Fos immunoreactive cells significantly as compared to controls within the medial parvocellular part of paraventricular nucleus (PVN). Form:Liquid
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Ispronicline
CAS number：252870-53-4 molecular formula：C14H22N2O
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| Chinese alias | - | ||
| English alias | RPCVIAXDAUMJJP-PZBABLGHSA-N | (2S,4E)-N-Methyl-5-[5-(1-methylethoxy)pyridin-3-yl]pent-4-en-2-amine | N-Benzyloxycarbonyl-DL-3-phenylalanine | MS-23356 | Timogen | UNII-3E05NBH9V5 | 3E05NBH9V5 | (E,2S)-N-methyl-5-(5-propan-2-yloxypyridin-3-yl)pent-4-en-2-a | ||
| CAS number | 252870-53-4 | molecular formula | C14H22N2O |
| molecular weight | 234.34 g/mol | Exact mass | ≥98% |
| PSA | 34.200 Ų | logp | 2.5 |
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