compound introduction
AJ-76 HCL是多巴胺自身受体的选择性拮抗剂，可显示多巴胺能神经元的腹腔放电速率降低。研究表明，AJ-76 HCL在具有部分病变的神经元中增加黑质纹状体系统中的多巴胺合成。众所周知，AJ-76 HCL对多巴胺受体的作用与可卡因相似。基于这些特性，该化合物对于研究可卡因对神经元多巴胺释放的影响至关重要。 AJ-76 HCL is a selective antagonist of dopamine autoreceptors, which displays a reduction in ventral firing rates of dopaminergic neurons. Studies indicate that AJ-76 HCL increases dopamine synthesis in the nigrostriatal system in neurons with partial lesions. It is known that the effects of AJ-76 HCL displays similar effects on dopamine receptors as cocaine. Based on these properties this compound is essential in studying the effects of cocaine on dopamine release from neurons.
