N-异丁酰基-L-半胱氨酸是一种硫醇化合物，可在涉及氨基酸的OPA分析中区分手性。通过N-异丁酰基-L-半胱氨酸的偶极矩与单链DNA的负电荷之间的相互作用，将N-异丁酰基-L-半胱氨酸与单层表面上的金颗粒一起使用以分离单链DNA。这些研究确定，N-异丁酰基-L-半胱氨酸与金纳米颗粒一起在振动圆二色性（VCD）和圆二色性（CD）光谱中是必不可少的工具。此外，与D形式相比，L异构体在松弛DNA的吸附上更有效，D形式导致DNA超螺旋并导致较弱的结合强度。 N-Isobutyryl-L-cysteine is a thiol compound, which distinguishes chirality in assays involving amino acids with OPA. N-Isobutyryl-L-cysteine is employed along with gold particles on a monolayer surface to separate single stranded DNA, via the interaction between the dipole moment of N-Isobutyryl-L-cysteine and the negative charge of single stranded DNA. These studies determined that N-Isobutyryl-L-cysteine is an essential tool along with gold nanoparticles in vibrational circular dichroism (VCD) and circular dichroism (CD) spectroscopy. Furthermore, the L isomer is more effective in adsorption of relaxed DNA compared to the D form which causes DNA to supercoil and results in a weaker binding strength.
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N-Isobutyryl-L-cysteine
CAS number：124529-02-8 molecular formula：C7H13NO3S
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compound introduction
Specs
| Chinese alias | - | ||
| English alias | (2R)-2-(2-methylpropanamido)-3-sulfanylpropanoic acid | N-(2-Methylpropionyl)-L-cysteine | (2R)-2-(2-methylpropanoylamino)-3-sulfanylpropanoic acid | N-Isobutyryl-L-cysteine | (R)-2-Isobutyramido-3-mercaptopropanoic acid | L-Cysteine, N-(2-methyl-1-oxopro | ||
| CAS number | 124529-02-8 | molecular formula | C7H13NO3S |
| molecular weight | 191.25 g/mol | Exact mass | ≥97% |
| PSA | 67.400 Ų | logp | 0.500 |
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124529-02-8 | N-Isobutyryl-L-cysteine.pdf
