3-Deazaadenosine HCl (3-DZA, c3Ado)是一种有效的 S-adenosylhomocysteine hydrolase 的抑制剂，Ki值为3.9 μM。3-Deazaadenosine HCl 可抑制细菌脂多糖诱导的 TNF-α 和 IL-1β 的转录。3-Deazaadenosine HCl 可抑制 NF-κB 的转录活性，阻止FCS诱导的 Ras 的羧基甲基化，并降低FCS诱导的 ERK1/2 和 Akt 磷酸化。3-Deazaadenosine HCl 具有抗炎、抗增殖和抗HIV的活性。 Information 3-Deazaadenosine hydrochloride 3-Deazaadenosine HCl (3-DZA, c3Ado) is a potent inhibitor of S-adenosylhomocysteine hydrolase with Ki of 3.9 µM. 3-Deazaadenosine HCl inhibits bacterial lipopolysaccharide-induced transcription of TNF-α and IL-1β . 3-Deazaadenosine HCl inhibits the transcriptional activity of NF-κB , prevents FCS-induced Ras carboxyl methylation and reduces FCS-induced ERK1/2 and Akt phosphorylation. 3-Deazaadenosine HCl has anti-inflammatory, anti-proliferative and anti-HIV activities. Targets S-adenosylhomocysteine hydrolase (Cell-free assay) 3.9 μM(Ki)
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3-Deazaadenosine hydrochloride
CAS number：86583-19-9 molecular formula：C11H15ClN4O4
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| Chinese alias | - | ||
| English alias | 3-DZA HCl | c3Ado HCl1H-Imidazo[4,5-c]pyridin-4-amine,1-β-D-ribofuranosyl-,monohydrochloride (9CI) | ||
| CAS number | 86583-19-9 | molecular formula | C11H15ClN4O4 |
| molecular weight | 302.71 g/mol | Exact mass | 10mM in DMSO |
| PSA | 127.000 Ų | logp | -1.07 |
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